Acute effects of hemodialysis on erythrocyte sodium fluxes in uremic patients

The acute effects of both acetate and bicarbonate hemodialysis on erythrocyte transmembrane sodium fluxes were investigated in 15 patients with chronic uremia. We observed a significance (p less than 0.01) stimulation of the Na+,K+ pump in both procedures, with a significant correlation to the amoun...

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Published inNephron (2015) Vol. 41; no. 1; p. 22
Main Authors Quarello, F, Boero, R, Guarena, C, Rosati, C, Giraudo, G, Giacchino, F, Piccoli, G
Format Journal Article
LanguageEnglish
Published Switzerland 1985
Subjects
Acetates
Adult
Aged
Bicarbonates
Cell Membrane Permeability
Erythrocytes - metabolism
Female
Humans
Ion Channels - metabolism
Lithium - blood
Male
Middle Aged
Potassium - blood
Renal Dialysis - adverse effects
Sodium - blood
Uremia - blood
Uremia - therapy
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Summary:The acute effects of both acetate and bicarbonate hemodialysis on erythrocyte transmembrane sodium fluxes were investigated in 15 patients with chronic uremia. We observed a significance (p less than 0.01) stimulation of the Na+,K+ pump in both procedures, with a significant correlation to the amount of fluid removed during hemodialysis (r = 0.56, p less than 0.03). Outward Na+ cotransport fluxes significantly rose (p less than 0.05) after acetate hemodialysis and decreased (p less than 0.05) after bicarbonate hemodialysis. Minor and not significant pre- and posthemodialysis bidirectional changes were observed as regards the intraerythrocyte Na+ and K+ concentration, passive Na+ and K+ permeability, and Na+,Li+ countertransport. Hemodialysis may acutely affect the erythrocyte sodium pump and cotransport fluxes, possibly through the modulation of hormonal factors triggered by the extracellular volume changes.
ISSN:1660-8151
2235-3186
DOI:10.1159/000183540