Multiple Aspergillus brain abscesses in immuno-competent patient with severe cranio-facial trauma

• Published in: Acta neurochirurgica Vol. 149; no. 6; pp. 629 - 632
• Main Authors: Marinovic, T, Skrlin, J, Vilendecic, M, Rotim, K, Grahovac, G
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.06.2007
• Subjects: Aged; Amphotericin B - administration & dosage; Antifungal Agents - administration & dosage; Aspergillus; Brain Abscess - diagnosis; Brain Abscess - drug therapy; Brain Abscess - immunology; Brain Abscess - surgery; Cerebral Ventricles - surgery; Cerebrospinal Fluid Shunts; Combined Modality Therapy; Drug Administration Schedule; Facial Injuries - surgery; Humans; Hydrocephalus - surgery; Immunocompetence - immunology; Itraconazole - administration & dosage; Male; Maxillary Fractures - surgery; Meningitis, Fungal - diagnosis; Meningitis, Fungal - drug therapy; Meningitis, Fungal - immunology; Meningitis, Fungal - surgery; Microsurgery; Motor Cortex - surgery; Nervous system; Neuroaspergillosis - diagnosis; Neuroaspergillosis - drug therapy; Neuroaspergillosis - immunology; Neuroaspergillosis - surgery; Neuronavigation; Osteotomy, Le Fort; Postoperative Complications - diagnosis; Postoperative Complications - drug therapy; Postoperative Complications - immunology; Postoperative Complications - surgery; Reoperation; Skull Fractures - surgery; Tomography, X-Ray Computed
• ISSN: 0001-6268; 0942-0940
• DOI: 10.1007/s00701-007-1148-7

Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stereotactic drainage and, with Amphotericin B, Liposomal Amphotericin B, and Itraconazol.