Comparative Evaluation of the Antiherpes Activity of Compounds with Different Mechanisms of Action

Experiments on cell cultures addressed the antiviral properties of 2-anilino-4,6-di- tert -butylphenol and N-(3,5-di- tert -2-hydroxyphenyl)acetamide, both of which are o -aminophenol derivatives, and 3,4-dihydroxy-benzoic acid against herpes simplex virus and in experimental cutaneous herpes in whi...

Full description

Saved in:
Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 53; no. 7; pp. 646 - 649
Main Authors Shadyro, O. I., Sorokin, V. L., Ksendzova, G. A., Savinova, O. V., Samovich, S. N., Boreko, E. I.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2019
Springer
Subjects
Acyclovir
Animal experimentation
Benzoic acid
Epidemiology
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Resveratrol
herpes simplex virus
3,4-dihydroxybenzoic acid
acyclovir
experimental cutaneous herpes
aminophenol derivatives
Online AccessGet full text

Cover

More Information
Summary:Experiments on cell cultures addressed the antiviral properties of 2-anilino-4,6-di- tert -butylphenol and N-(3,5-di- tert -2-hydroxyphenyl)acetamide, both of which are o -aminophenol derivatives, and 3,4-dihydroxy-benzoic acid against herpes simplex virus and in experimental cutaneous herpes in white mice. Assessment of the data obtained here indicates that all three study compounds were significantly less active than acyclovir in cell cultures. In experiments on laboratory animals, the efficacy of ointment containing N-(3,5-di- tert -2-hydroxyphenyl) acetamide was comparable with that of acyclovir ointment, while ointments containing 2-anilino-4,6-di- tert -butylphenol and 3,4-dihydroxybenzoic acid were less active.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-019-02055-3