Effect of Repeated Doses of Dexamethasone on the Incidence and Severity of Respiratory Distress Syndrome in Multifetal Gestation between 24 and 34 Weeks

The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers wi...

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Bibliographic Details
Published inGynecologic and obstetric investigation Vol. 52; no. 1; pp. 26 - 33
Main Authors Al-Yatama, M.K., Al Essa, M., Omu, A.E., Al-Shamali, I., Egbase, P., Rashwan, N.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.01.2001
S. Karger AG
Subjects
Adrenal Cortex Hormones - administration & dosage
Biological and medical sciences
Delivery. Postpartum. Lactation
Dexamethasone - administration & dosage
Disorders
Female
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Kuwait
Medical sciences
Original Paper
Pharmacology. Drug treatments
Pregnancy
Pregnancy, Multiple - drug effects
Respiratory Distress Syndrome, Newborn - drug therapy
Respiratory system
Tropical medicine
Kuwait
Asia
Respiratory distress syndrome
Multifetal gestation
Dexamethasone
Human
Corticosteroid
Chemoprophylaxis
Respiratory disease
Treatment efficiency
Maternal treatment
Incidence
Multiple dose
Prenatal
Prevention
Newborn diseases
Clinical stage
Multiple pregnancy
Respiratory distress
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Summary:The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies, who only had one course of dexamethasone, were compared with controls. Corticosteroid therapy was associated with a reduction in moderate to severe RDS in all groups (twins p < 0.01, triplets and quadruplets p < 0.008) and the emergency group with dexamethasone therapy (p < 0.036) when compared to their individual controls. Dexamethasone reduced the duration of stay in the neonatal intensive care unit of the emergency twin group (p < 0.01). Neonatal birth weights were significantly less in all groups treated with repeated doses in comparison to the controls.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0378-7346
1423-002X
DOI:10.1159/000052936