Effect of Repeated Doses of Dexamethasone on the Incidence and Severity of Respiratory Distress Syndrome in Multifetal Gestation between 24 and 34 Weeks
The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers wi...
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Published in | Gynecologic and obstetric investigation Vol. 52; no. 1; pp. 26 - 33 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Basel, Switzerland
Karger
01.01.2001
S. Karger AG |
Subjects | |
Online Access | Get full text |
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Summary: | The objective of the study was to evaluate the effects of antenatal corticosteroid therapy in multiple pregnancy on the incidence and severity of respiratory distress syndrome (RDS). Twenty-two women with twin, 12 with triplet and 2 with quadruplet pregnancies and an emergency group of 20 mothers with twin pregnancies, who only had one course of dexamethasone, were compared with controls. Corticosteroid therapy was associated with a reduction in moderate to severe RDS in all groups (twins p < 0.01, triplets and quadruplets p < 0.008) and the emergency group with dexamethasone therapy (p < 0.036) when compared to their individual controls. Dexamethasone reduced the duration of stay in the neonatal intensive care unit of the emergency twin group (p < 0.01). Neonatal birth weights were significantly less in all groups treated with repeated doses in comparison to the controls. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-7346 1423-002X |
DOI: | 10.1159/000052936 |