JD-30, an active fraction extracted from Danggui–Shaoyao–San, decreases β-amyloid content and deposition, improves LTP reduction and prevents spatial cognition impairment in SAMP8 mice

• Published in: Experimental gerontology Vol. 47; no. 1; pp. 14 - 22
• Main Authors: Hu, Zeng-Yao, Liu, Gang, Cheng, Xiao-Rui, Huang, Yan, Yang, Sheng, Qiao, Shan-Yi, Sun, Lei, Zhou, Wen-Xia, Zhang, Yong-Xiang
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 2012
• Subjects: Alzheimer Disease - physiopathology; Alzheimer Disease - prevention & control; Alzheimer's disease (AD); Amyloid beta-Peptides - drug effects; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Animals; Brain Chemistry - drug effects; Cognition Disorders - physiopathology; Cognition Disorders - prevention & control; Danggui–Shaoyao–San (DSS); Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Electrophysiological Phenomena - drug effects; Female; Gene Expression; Hippocampus - drug effects; JD-30; Long-term potentiation (LTP); Long-Term Potentiation - drug effects; Male; Maze Learning - drug effects; Memory - drug effects; Mice; Mice, Inbred Strains; Senescence-accelerated mouse prone-8 (SAMP8); Spatial Behavior - drug effects; Spatial learning and memory; β-amyloid (Aβ); APP; JD-30; AD; DG; PS; DSS; Long-term potentiation (LTP); LTP; Alzheimer's disease (AD); IDE; β-amyloid (Aβ); Spatial learning and memory; BACE1; Aβ; CatB; HFS; Danggui–Shaoyao–San (DSS); Senescence-accelerated mouse prone-8 (SAMP8); SAMP8; NEP; GAPDH; PCR; IOD
• ISSN: 0531-5565; 1873-6815; 1873-6815
• DOI: 10.1016/j.exger.2011.09.009

JD-30 is an active fraction extracted from Danggui–Shaoyao–San (DSS), a traditional Chinese medicinal prescription. We previously showed that JD-30 could alleviate cognitive dysfunction of the mice induced by intracerebroventricular injection of β-amyloid (Aβ). However, data remain scarce on the effect of JD-30 on an Alzheimer's disease (AD) model and the underlying mechanisms are unknown. Further detailed studies on the effects of JD-30 on spatial cognition of senescence-accelerated mouse prone 8 (SAMP8), a suitable rodent model for cognitive impairment of aged subjects were investigated to elucidate the possible mechanisms. Long-term treatment with JD-30 significantly decreased the prolonged latency of SAMP8 in the Morris water-maze test. It also ameliorated the reduction of long-term potentiation (LTP) and reduced the damage of neurons in the hippocampus of SAMP8. Finally, JD-30 decreased the content and deposition of Aβ in the brain of SAMP8. The results show that JD-30 improves deterioration of spatial learning and memory in the SAMP8 mouse model, and by decreasing the content and deposition of Aβ, neuronal activity and synaptic plasticity improve, suggesting one of the mechanisms involved. ► JD-30 improves spatial recognition impairment and LTP reduction of SAMP8. ► JD-30 protects the neuron from damage. ► JD-30 decreases β-amyloid content and deposition. ► JD-30 is a neuroprotective against age-related senescence. ► JD-30 is a potential therapeutic agent for AD treatment.