Histoimmunological discrepancies in primary IgA nephropathy and anaphylactoid purpura sustain relationships between mucosa and kidney

Immunohistomorphometric analysis of the tonsils from a series of patients with anaphylactoid purpura or Berger's disease showed abnormal proportions of gamma- and alpha-isotype-producing cells. Conversely, renal immunofluorescence (IF) performed on kidney biopsies from 2 patients with hematuria...

Full description

Saved in:
Bibliographic Details
Published inNephron (2015) Vol. 43; no. 3; p. 214
Main Authors Bene, M C, Hurault de Ligny, B, Faure, G, Kessler, M, Duheille, J
Format Journal Article
LanguageEnglish
Published Switzerland 1986
Subjects
Adult
Female
Glomerulonephritis, IGA - immunology
Glomerulonephritis, IGA - pathology
Humans
Immunoglobulin A - metabolism
Immunoglobulin G - metabolism
Kidney - immunology
Kidney - pathology
Male
Middle Aged
Mucous Membrane - immunology
Mucous Membrane - pathology
Palatine Tonsil - immunology
Palatine Tonsil - pathology
Purpura, Schoenlein-Henoch - immunology
Purpura, Schoenlein-Henoch - pathology
Online AccessGet more information

Cover

More Information
Summary:Immunohistomorphometric analysis of the tonsils from a series of patients with anaphylactoid purpura or Berger's disease showed abnormal proportions of gamma- and alpha-isotype-producing cells. Conversely, renal immunofluorescence (IF) performed on kidney biopsies from 2 patients with hematuria and clinical symptoms suggestive of one or the other of these conditions failed to confirm the suspected diagnosis. Immunohistomorphometric analysis of these patient's tonsils showed normal proportions of gamma- and alpha-isotype-producing cells. These negative results suggest that strong relationships exist between mucosal abnormalities and renal deposition of IgA in hematuria.
ISSN:1660-8151
DOI:10.1159/000183832