Assessment of dynamic corneal response parameters in Chinese patients of different ages with myopia and orthokeratology lenses using the Corvis ST

• Published in: Contact lens & anterior eye Vol. 47; no. 2; p. 102123
• Main Authors: Zhang, Shuxian, Liu, Jinghua, Gao, Juan, Yan, Yarong, Hao, Peng, Li, Xuan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2024
• Subjects: Children and adolescents myopia; Dynamic corneal response; Myopia prevention and control; Orthokeratology; Dynamic corneal response; Myopia prevention and control; Orthokeratology; Children and adolescents myopia
• ISSN: 1367-0484; 1476-5411; 1476-5411
• DOI: 10.1016/j.clae.2024.102123

•The dynamic changes in DCRs of OK lens users were observed at various time points.•Most DCRs changes significantly within the initial 6 months after OK lenses usage.•The stability period for DCRs occurs later than for optometry parameters.•Minimal variation in DCRs is observed at the same follow-up time point among OK lens users of different ages.•Certain DCR might serve as predictors of myopic progression in children. To investigate the effects of orthokeratology lenses (OK lenses) on corneal biomechanics in subjects of different ages. Fifty subjects with mild to moderate myopia were categorized into three groups (Group I-III) based on their age. Corvis ST was used to collect dynamic corneal response parameters (DCRs) at different follow-up time points. Repeated measures analysis of variance combined with simple effect analysis was used to analyze the changes in DCRs in different groups during the follow-up period. Multiple linear regression analysis was used to analyze the correlations between axial length growth (ALG) at 6 months (ALG-6M) or 12 months (ALG-12M) and sex, baseline spherical equivalent refraction (SER), and DCRs. The DCRs changed in all three groups after wearing OK lenses. Most DCRs showed significant differences between baseline and 6 months after wearing OK lenses, while the differences between DCRs at 6 months and 12 months were not statistically significant. No significant differences in DCRs were observed among the three groups at the same follow-up time point. Additionally, at 6 months post-OK lens wear, ALG-6M was significantly correlated with velocity of the corneal apex at the first applanation (A1V-6M) (P = 0.002), Corvis biomechanical index (CBI-6M) (P = 0.004), the maximum amount of corneal movement (DAM-6M) (P = 0.010), deformation amplitude ratio of 2 mm (DAR2-6M) (P = 0.010), and stress–strain index (SSI-6M) (P = 0.038) in Group I. Furthermore, ALG-12M showed significant correlations with SSI-6M (P = 0.031), peak distance at the DAM (PD)-6M (P = 0.037), baseline Ambrósio Relational Thickness to the horizontal profile (P = 0.013) in Group I. The majority of DCRs displayed significant changes within the initial 6 months of OK lens wear. Minimal variation in DCRs was observed across different age groups at the same follow-up time point. Certain DCR parameters exhibited correlations with ALG, suggesting their potential in predicting ALG in myopic children undergoing OK lenses correction.