Opiate receptor subtypes in the regulation of thyrotropin and prolactin secretion in the rat

In the present study both MR 2034 (kappa-agonist) and DAMME (mu-agonist) decreased thyrotropin (TSH) secretion stimulated by cold in the rat when infused into the 3rd ventricle. After infusion into the posterior hypothalamus (PH), a small dose of MR 2034 increased the TSH response to cold whereas ot...

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Bibliographic Details
Published inHormone research Vol. 29; no. 5-6; p. 218
Main Authors Rauhala, P, Tuominen, R K, Männistö, P T
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1988
Subjects
Animals
Benzomorphans - pharmacology
Cerebral Ventricles - drug effects
Cerebral Ventricles - physiology
D-Ala,MePhe,Met-ol-enkephalin - administration & dosage
D-Ala,MePhe,Met-ol-enkephalin - pharmacology
Injections, Intraventricular
Kinetics
Male
Morphinans - pharmacology
Prolactin - blood
Prolactin - secretion
Rats
Rats, Inbred Strains
Receptors, Opioid - drug effects
Receptors, Opioid - physiology
Receptors, Opioid, kappa
Receptors, Opioid, mu
Reference Values
Thyrotropin - blood
Thyrotropin - secretion
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Summary:In the present study both MR 2034 (kappa-agonist) and DAMME (mu-agonist) decreased thyrotropin (TSH) secretion stimulated by cold in the rat when infused into the 3rd ventricle. After infusion into the posterior hypothalamus (PH), a small dose of MR 2034 increased the TSH response to cold whereas other doses did not. The stimulatory (at PH) but not the inhibitory (at 3rd ventricle) effect of MR 2034 was antagonized by naloxone. DAMME had no statistically significant effect at this location. Both the mu- and kappa-agonist stimulated prolactin secretion when infused into the 3rd ventricle, but DAMME was more effective than MR 2034. Furthermore, the stimulatory effect of DAMME, but not that of MR 2034, on prolactin secretion was antagonized by naloxone.
ISSN:0301-0163
DOI:10.1159/000181007