DNA-ploidy, morphometric-stereological and P-glycoprotein study of superficial bladder carcinomas

• Published in: European urology Vol. 21 Suppl 1; p. 16
• Main Authors: Sanchez-Fernandez de Sevilla, M C, Gil-Salmon, M, Perez-Bacete, M, Morell-Quadreny, L, Martinez-Diaz, F, Iborra-Juan, I, Fenollosa-Entrena, B, Llombart-Bosch, A
• Format: Journal Article
• Language: English
• Published: Switzerland 1992
• Subjects: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor - analysis; DNA, Neoplasm - analysis; Female; Follow-Up Studies; Humans; Male; Membrane Glycoproteins - analysis; Neoplasm Proteins - analysis; Ploidies; Urinary Bladder Neoplasms - chemistry; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology
• ISSN: 0302-2838
• DOI: 10.1159/000474881

We carried out a DNA-ploidy, morphometric-stereologic and P-glycoprotein study on 40 newly diagnosed superficial bladder cancer patients (G1-G2), correlating the results with histological grade and clinical outcome. Variations in the number of patients who present recurrences, progression or remain tumor-free during the whole follow-up period (at least 5 years) were not significant when related to nuclear size, proliferative diploid index, presence of aneuploidy and expression of P-glycoprotein. It is striking how the majority of disease-free subjects showed a proliferative diploid index higher than 10%. Moreover, 3 of them presented an aneuploid cell population. In our study, only histological grade showed a significant discriminatory level in terms of progression versus no progression in patients with superficial bladder cancer.