Remedial effects of tilapia skin peptides against dexamethasone-induced muscle atrophy in mice by modulation of AKT/FOXO3a and Sirt1/PGC-1α signaling pathways
[Display omitted] •TSP provides protection against DEX-induced muscle atrophy.•TSP inhibits the expression of ubiquitin protease system.•TSP regulates the Sirt1/PGC-1 and AKT/FOXO3a signaling pathways. Tilapia skin peptides (TSP) possess a range of physiological activities. This study aimed to explo...
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Published in | Journal of functional foods Vol. 113; p. 105954 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.02.2024
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•TSP provides protection against DEX-induced muscle atrophy.•TSP inhibits the expression of ubiquitin protease system.•TSP regulates the Sirt1/PGC-1 and AKT/FOXO3a signaling pathways.
Tilapia skin peptides (TSP) possess a range of physiological activities. This study aimed to explore the effects of TSP on Dexamethasone (DEX)-induced muscle atrophy. In vitro, C2C12 myotube myotube diameter and expression levels of the muscle-specific E3 ubiquitin ligases F-box only protein 32 (Atrogin-1) and muscle ring finger protein 1 (MuRF1) challenged with DEX were reversed by TSP. In vivo, DEX was injected subcutaneously to build muscle atrophy model mice. TSP enhanced grip strength, running distance, body lean muscle content, cross-sectional area of the gastrocnemius and tibialis anterior muscles of DEX-induced mice. Moreover, TSP inhibited the expression levels of Atrogin-1 and MuRF1. Mechanically, TSP improved DEX-induced muscle atrophy by regulating the Protein Kinase B α (AKT)/Forkhead box O3 protein (FOXO3a), Sirtuin 1 (Sirt1)/peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) signaling pathway, and downstream factors such as nuclear respiratory factor (NRF)1/2 and mitochondrial transcription factor A (TFAM). |
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ISSN: | 1756-4646 2214-9414 |
DOI: | 10.1016/j.jff.2023.105954 |