Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin, its Aminomethylated Derivative, and their Inclusion Complexes with Cyclodextrin

The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in cyclodextrin were compared. The results indicated that DHQ and KH-14 had comparable antioxidant activities. The antioxidant activities of DHQ and KH-14 were prese...

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Published inPharmaceutical chemistry journal Vol. 55; no. 8; pp. 778 - 780
Main Authors Rogovskii, V. S., Matyushin, A. I., Koroteev, A. M., Koroteev, M. P., Pozdeev, A. O., Knyazev, V. V., Shimanovsky, N. L.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2021
Springer
Subjects
Anti-inflammatory drugs
Antioxidants
Bioflavonoids
Carrageenin
Cyclodextrins
Flavones
Flavonoids
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
KH-14
taxifolin
antioxidant activity
cyclodextrin
anti-inflammatory activity
dihydroquercetin
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Summary:The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in cyclodextrin were compared. The results indicated that DHQ and KH-14 had comparable antioxidant activities. The antioxidant activities of DHQ and KH-14 were preserved upon formation of the inclusion complexes in cyclodextrin. Taxifolin, KH-14, and the water-soluble inclusion complex of KH-14 in cyclodextrin at a dose of 0.04 mmol/kg exhibited pronounced anti-inflammatory effects on the model of carrageenan-induced paw edema in mice that were equivalent to that of diclofenac at a dose of 0.02 mmol/kg.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-021-02493-y