Autoantibodies to nuclear mitotic apparatus in a patient with vitiligo and autoimmune thyroiditis

Circulating autoantibodies against the nuclear mitotic apparatus (NuMA) protein have been detected in sera of patients with a variety of connective tissue diseases. A close relation of anti-NuMA antibodies to define subsets of these diseases could not be established. This is the first description of...

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Bibliographic Details
Published inDermatology (Basel) Vol. 186; no. 3; p. 229
Main Authors Auer-Grumbach, P, Stangl, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1993
Subjects
Adult
Autoantibodies - analysis
Female
Humans
Spindle Apparatus - immunology
Thyroiditis, Autoimmune - immunology
Vitiligo - immunology
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Summary:Circulating autoantibodies against the nuclear mitotic apparatus (NuMA) protein have been detected in sera of patients with a variety of connective tissue diseases. A close relation of anti-NuMA antibodies to define subsets of these diseases could not be established. This is the first description of a patient with vitiligo, autoimmune thyroiditis and a high titer of antibodies against NuMA on Hep-2 cells. The possibility of a beginning of multiple autoimmune syndrome cannot be excluded.
ISSN:1018-8665
DOI:10.1159/000247353