Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

Abstract In extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates ( n  = 44) who had undergone ECLS for noncardiac indications...

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Published inJournal of pediatric intensive care Vol. 7; no. 1; pp. 007 - 013
Main Authors Daniel, John M., Bernard, Philip A., Skinner, Sean C., Bhandary, Prasad, Ruzic, Ana, Bacon, Matthew K., Ballard, Hubert O.
Format Journal Article
LanguageEnglish
Published Stuttgart · New York Georg Thieme Verlag KG 01.03.2018
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Original
Original Article
neonatal
extracorporeal membrane oxygenation
complications
oxygenator
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Summary:Abstract In extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates ( n  = 44) who had undergone ECLS for noncardiac indications from 2009 to 2015. Between the two groups (PMP n  = 21, PP n  = 23), the PP oxygenators failed 91% of the time, whereas the PMP oxygenators failed 43% of the time ( p  < 0.05). Analysis suggests PMP oxygenators are less prone to failure than PP oxygenators, and they require fewer number of oxygenator changes during a neonatal ECLS.
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ISSN:2146-4618
2146-4626
DOI:10.1055/s-0037-1599150