The association of urinary 5-hydroxyindoleacetic acid and vanillylmandelic acid in patients with generalized anxiety

There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with gen...

Full description

Saved in:
Bibliographic Details
Published inNeuropsychobiology Vol. 31; no. 1; p. 6
Main Authors Garvey, M J, Noyes, Jr, R, Woodman, C, Laukes, C
Format Journal Article
LanguageEnglish
Published Switzerland 1995
Subjects
Anxiety Disorders - physiopathology
Anxiety Disorders - urine
Female
Humans
Hydroxyindoleacetic Acid - urine
Male
Middle Aged
Norepinephrine - metabolism
Norepinephrine - physiology
Serotonin - metabolism
Serotonin - physiology
Vanilmandelic Acid - urine
Online AccessGet more information

Cover

More Information
Summary:There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety disorder. There was a significant association between urinary levels of 5-HIAA and VMA: r = 0.79; p = 0.0001. Possible implications of this finding are discussed.
ISSN:0302-282X
DOI:10.1159/000119165