Electrocardiogram Monitoring: Computerized Detection of Ventricular Changes Induced by Drugs

Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantion. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring techni...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 179; no. 4080; pp. 1338 - 1340
Main Authors Berni, Albert J., Luttges, Marvin W., Dick, Donald E.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 30.03.1973
Subjects
Animals
Antibodies
Computers
Dosage
Dysrhythmias
Electrocardiography
Electrodes
Fibrillation
Heart rate
Heart Rate - drug effects
Heart Ventricles - drug effects
Lidocaine - pharmacology
Methods
Mice
Monitoring, Physiologic
Ouabain - pharmacology
Phenytoin - pharmacology
Serum albumins
Surface areas
Waveforms
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Summary:Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantion. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.179.4080.1338