Medial to lateral frontal functional connectivity mapping reveals the organization of cingulate cortex

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 34; no. 8
• Main Authors: Ducret, Marion, Giacometti, Camille, Dirheimer, Manon, Dureux, Audrey, Autran-Clavagnier, Delphine, Hadj-Bouziane, Fadila, Verstraete, Charles, Lamberton, Franck, Wilson, Charles R E, Amiez, Céline, Procyk, Emmanuel
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.08.2024; Oxford University Press (OUP)
• Subjects: Animals; Brain Mapping - methods; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - physiology; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - physiology; Life Sciences; Macaca mulatta; Magnetic Resonance Imaging - methods; Male; Neural Pathways - diagnostic imaging; Neural Pathways - physiology; Neurons and Cognition; cingulate cortex; non-human primate; functional connectivity; resting-state fMRI; prefrontal cortex
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhae322

The functional organization of the frontal lobe is a source of debate, focusing on broad functional subdivisions, large-scale networks, or local refined specificities. Multiple neurocognitive models have tried to explain how functional interactions between cingulate and lateral frontal regions contribute to decision making and cognitive control, but their neuroanatomical bases remain unclear. We provide a detailed description of the functional connectivity between cingulate and lateral frontal regions using resting-state functional MRI in rhesus macaques. The analysis focuses on the functional connectivity of the rostral part of the cingulate sulcus with the lateral frontal cortex. Data-driven and seed-based analysis revealed three clusters within the cingulate sulcus organized along the rostro-caudal axis: the anterior, mid, and posterior clusters display increased functional connectivity with, respectively, the anterior lateral prefrontal regions, face–eye lateral frontal motor cortical areas, and hand lateral frontal motor cortex. The location of these clusters can be predicted in individual subjects based on morphological landmarks. These results suggest that the anterior cluster corresponds to the anterior cingulate cortex, whereas the posterior clusters correspond to the face–eye and hand cingulate motor areas within the anterior midcingulate cortex. These data provide a comprehensive framework to identify cingulate subregions based on functional connectivity and local organization.