Difference between inactive renins in amniotic fluid and in control or pregnancy plasma

Phenylethylamine-agarose column chromatography has been used to compare inactive renins in amniotic fluid, in control plasma during estrogen treatment and in maternal plasma during normal pregnancy. Inactive renin in all three was retained by the column and separated from renin substrate. Inactive r...

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Bibliographic Details
Published inGynecologic and obstetric investigation Vol. 20; no. 1; p. 14
Main Authors Franks, R, Bodola, F, Renthal, R, Hayashi, R
Format Journal Article
LanguageEnglish
Published Switzerland 1985
Subjects
Amniotic Fluid - enzymology
Female
Humans
Pregnancy
Reference Values
Renin - analysis
Renin - blood
Renin - isolation & purification
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Summary:Phenylethylamine-agarose column chromatography has been used to compare inactive renins in amniotic fluid, in control plasma during estrogen treatment and in maternal plasma during normal pregnancy. Inactive renin in all three was retained by the column and separated from renin substrate. Inactive renin in control and maternal plasma desorbed similarly and was different than that in amniotic fluid. The results suggest that during normal pregnancy the elevated concentrations of inactive renin in maternal plasma are more likely of renal than placental origin.
ISSN:0378-7346
1423-002X
DOI:10.1159/000298965