Role of polymorphisms of the endothelial nitric oxide synthase gene in predicting slow-flow phenomenon after primary percutaneous coronary intervention

• Published in: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir Vol. 48; no. 5; pp. 472 - 483
• Main Authors: Kiani, Reza, Alilou, Sanam, Rafatnia, Shirin, Taslimi, Yasaman, Habibzadeh, Sima, Gharibzadeh, Safoora, Firouzi, Ata, Rahim, Shahin, Zahedmehr, Ali, Mehrvarz, Farzaneh, Moghadam Ahari, Mehrdad, Sadeghipour, Parham
• Format: Journal Article
• Language: English
• Published: Turkey KARE Publishing 01.07.2020
• Subjects: endothelial nitric oxide; gene polymorphism; no reflow; primary percutaneous coronary intervention; slow flow; st-segment elevation myocardial infarction
• ISSN: 1016-5169; 1308-4488; 1016-5169
• DOI: 10.5543/tkda.2020.53849

The aim of the present study was to examine the association between 2 polymorphisms of the endothelial nitric oxide (eNOS) gene (-786T>C and +894G>T) and the no-reflow/slow-flow phenomenon in post-primary percutaneous coronary intervention (PPCI) patients. A total of 103 post-PPCI patients were enrolled. Coronary no-reflow phenomenon was defined as a Thrombolysis in Myocardial Infarction (TIMI) flow grade 0-1 and coronary slow-flow phenomenon (CSFP) was defined as a TIMI flow grade ≤2. Due to the small number of post-PPCI patients with the no-reflow phenomenon (n=4), the primary comparison was made between CSFP (n=20) and normal flow (n=83) groups. There was a greater frequency of CSFP among carriers of the -786C allele of the eNOS -786T>C polymorphism (odds ratio [OR]: 3.90; 95% confidence interval [CI]: 0.87-17.45; p=0.07). However, no such association was detected between the +894T allele of the eNOS +894G>T and CSFP (OR: 0.92; 95% CI: 0.21-3.98; p=0.91). In the adjusted analysis, the -786T>C polymorphism did not reach statistical significance. There was no significant association between CSFP and 2 of the most common polymorphisms of the eNOS gene in post-PPCI patients.