Bartter's syndrome with normal chloride reabsorption during indomethacin treatment

A 17-year-old male patient with Bartter's syndrome was admitted for renal function studies. This patient had persistent hypokalemia, first found at age 5; the diagnosis of Bartter's syndrome with renal hypersecretion of prostaglandins E2 and F2 alpha had been established at age 13. A conge...

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Published inNephron (2015) Vol. 46; no. 2; p. 137
Main Authors Hornych, A, Huet de Barochez, Y, Bariéty, J, Branca, G F, Vigeral, P, Girard, J F, Kazatchkine, M, De Gennes, J L, Truffert, J, Bocquet, L
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Adolescent
Bartter Syndrome - drug therapy
Bartter Syndrome - metabolism
Electrolytes - blood
Fatty Acids - blood
Hormones - blood
Humans
Hyperaldosteronism - metabolism
Indomethacin - therapeutic use
Kidney - secretion
Kidney Function Tests
Male
Prostaglandins - blood
Prostaglandins - secretion
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Summary:A 17-year-old male patient with Bartter's syndrome was admitted for renal function studies. This patient had persistent hypokalemia, first found at age 5; the diagnosis of Bartter's syndrome with renal hypersecretion of prostaglandins E2 and F2 alpha had been established at age 13. A congenital defect of chloride reabsorption was expected, but after 4 years of indomethacin treatment no such defect was found. Withdrawal of indomethacin for 1 week resulted in profound hypokalemia and the appearance of a chloride reabsorption defect, with an excessive urinary PGE2 and PGF2 alpha excretion, and a parallel decrease in plasma prostaglandin precursors. The cause of Bartter's syndrome in this patient seems to be renal hyperprostaglandinism.
ISSN:1660-8151
DOI:10.1159/000184329