Trends in CAPD technique failure: Canada, 1981-1997

• Published in: Peritoneal dialysis international Vol. 21; no. 4; pp. 365 - 371
• Main Authors: Schaubel, DE, Blake, PG, Fenton, SS
• Format: Journal Article
• Language: English
• Published: Milton, ON Multimed 01.07.2001
• Subjects: Adolescent; Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Canada; Emergency and intensive care: renal failure. Dialysis management; Female; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory - adverse effects; Peritoneal Dialysis, Continuous Ambulatory - statistics & numerical data; Peritoneal Dialysis, Continuous Ambulatory - trends; Peritonitis - etiology; Renal Dialysis - statistics & numerical data; Survival Analysis; Treatment Failure; Canada; North America; America; Human; Extrarenal dialysis; Ambulatory; Epidemiology; Peritoneal dialysis; Failure
• ISSN: 0896-8608; 1718-4304
• DOI: 10.1177/089686080102100406

Although important enhancements to continuous ambulatory peritoneal dialysis (CAPD) have occurred since its inception, few studies have explicitly evaluated trends over time in CAPD technique failure rates. To assist in quantifying the net benefit of improvements to CAPD for patient outcomes, we examined trends in technique failure rates among Canadian CAPD patients. Patients initiating renal replacement therapy on CAPD (n = 7110) between 1981 and 1997. Technique failure (i.e., switch to hemodialysis). Total follow-up was 12,831 patient-years (pt-yr). There were 1976 technique failures, for a crude CAPD failure rate of 154.0/1000 pt-yr. Technique failure rate ratios (RR) estimated using Poisson regression and adjusted for age, gender, race, province, primary renal diagnosis, and follow-up time, were significantly reduced for the 1990-93 [RR = 0.75, 95% confidence interval (CI) = (0.68, 0.83)], 1994-95 [RR = 0.83, CI (0.75, 0.93)], and 1996-97 [RR = 0.78, CI (0.70, 0.87)] calendar periods relative to 1981-89 (RR = 1, reference). Among cause-specific technique failure rates, the greatest improvement was observed for peritonitis-attributable technique failure, with RR = 0.46, CI (0.41, 0.50) for 1990-97 relative to 1981-89. However, rates of technique failure due to inadequate dialysis were significantly elevated for the 1990-97 period [RR = 1.68, CI (1.44, 1.96)]. The collection of more detailed data on practice patterns would enable future studies to elucidate the cause-and-effect relationship between CAPD descriptors and technique failure, and hence assist in clinical decision-making.