Antidiabetic influence of quercetin in streptozotocin-induced diabetic rats

• Published in: Nutrition research (New York, N.Y.) Vol. 24; no. 5; pp. 373 - 381
• Main Authors: Shetty, A.K, Rashmi, R, Rajan, M.G.R, Sambaiah, K, Salimath, P.V
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2004; Elsevier Science
• Subjects: antioxidant activity; apples; Biological and medical sciences; blood glucose; Diabetes; diabetes mellitus; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; ethnobotany; experimental diets; Fasting blood sugar; fatsting blood sugar; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; glucose tolerance; glycemic control; glycemic effect; Medical sciences; medicinal properties; nutrient intake; nutritional intervention; onions; Quercetin; tea; urine; Urine sugar; Urine volume; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Diabetes; Urine sugar; Urine volume; Fasting blood sugar; Quercetin; Endocrinopathy; Vertebrata; Mammalia; Rat; Diabetes mellitus; Rodentia; Streptozotocin
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/j.nutres.2003.11.010

The effect of feeding quercetin at the level of 1 g per kilogram of diet was studied in rats with streptozotocin-induced diabetes. The study involved a comparison between a starch-fed diabetic group and quercetin-fed diabetic group. The rats were examined for diet intake, water intake, gain in body weight, urine output, urine sugar, and fasting blood sugar. Diabetic status in rats was found to be ameliorated about 25% in rats fed with quercetin.