Genetic regulation of the development of glomerular sclerotic lesions in the BUF/Mna rat

BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria (greater than 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL devel...

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Published inNephron (2015) Vol. 54; no. 4; p. 334
Main Authors Matsuyama, M, Ogiu, T, Kontani, K, Yamada, C, Kawai, M, Hiai, H, Nakamura, T, Shimizu, F, Toyokawa, T, Kinoshita, Y
Format Journal Article
LanguageEnglish
Published Switzerland 1990
Subjects
Albuminuria - urine
Animals
Crosses, Genetic
Female
Genes, Recessive
Glomerulonephritis - genetics
Glomerulosclerosis, Focal Segmental - genetics
Glomerulosclerosis, Focal Segmental - urine
Male
Rats
Rats, Inbred Strains
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Summary:BUF/Mna strain rats spontaneously develop renal glomerular sclerotic lesions (RSL) at a nearly 100% incidence, diagnosed by hyperalbuminuria (greater than 500 mg/dl) and glomerular lesions morphologically resembling one type of human focal glomerular sclerosis (FGS). Genetic segregation of RSL development was studied by crossing the BUF/Mna strain with two other rat strains, WKY/NCrj and ACI/NMs, which were free of RSL. Two autosomal recessive genes in the BUF/Mna rats were found to determine the susceptibility to RSL in both combinations of crosses.
ISSN:1660-8151
DOI:10.1159/000185890