Theophylline metabolism in preterm neonates during the first weeks of life

The effects of prenatal steroids on theophylline metabolism in infants of 27-32 weeks gestation was studied. Although in utero exposure to betamethasone was associated with a more mature theophylline metabolite pattern in the first days of life, initial elimination half-life (t1/2 beta) did not diff...

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Bibliographic Details
Published inDevelopmental pharmacology and therapeutics Vol. 7; no. 4; p. 239
Main Authors Baird-Lambert, J, Doyle, P E, Thomas, D, Jager-Roman, E, Cvejic, M, Buchanan, N
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1984
Subjects
Betamethasone - therapeutic use
Female
Half-Life
Humans
Infant, Newborn
Infant, Premature
Kidney - metabolism
Liver - metabolism
Maternal-Fetal Exchange
Pregnancy
Theophylline - metabolism
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Summary:The effects of prenatal steroids on theophylline metabolism in infants of 27-32 weeks gestation was studied. Although in utero exposure to betamethasone was associated with a more mature theophylline metabolite pattern in the first days of life, initial elimination half-life (t1/2 beta) did not differ significantly between groups. By the second or third week of life the metabolite pattern was similar in all infants. The decline in t1/2 beta seen during theophylline treatment was not directly related to increased metabolite formation. These data suggest that other factors, such as renal clearance, are more important in determining the pharmacokinetics of theophylline in neonates than is hepatic metabolism.
ISSN:0379-8305
DOI:10.1159/000457170