Advanced adipose-derived stem cell protein extracts with antioxidant activity modulates matrix metalloproteinases in human dermal fibroblasts

Highlights ▸ AAPE at 2 μg/ml specifically exhibits scavenging activity of hydrogen peroxide and reducing power. ▸ AAPE increases activities of MMP-1 and MMP-2 in human dermal fibroblasts. ▸ The level of MMP-1 expression is decreased in a dose dependent manner by AAPE. ▸ The expression level of p-ERK...

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Published inEnvironmental toxicology and pharmacology Vol. 34; no. 2; pp. 263 - 271
Main Authors Chae, Yong-Byung, Lee, Jae Seol, Park, Hye-Jung, Park, In-Hwan, Kim, Moon-Moo, Park, Ye-Hyoung, Kim, Dong-Soo, Lee, Jong-Hwan
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2012
Subjects
Adipose Tissue - cytology
Adult
Antioxidants - pharmacology
Cell Extracts - pharmacology
Cell Line
Cell Survival - drug effects
Emergency
Female
Fibroblasts - drug effects
Fibroblasts - metabolism
Humans
Lipid Peroxidation - drug effects
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 2 - metabolism
Nuclear Proteins - metabolism
Skin - cytology
Stem Cells
Transcription Factor AP-1 - metabolism
Advanced adipose-derived stem cell protein extracts
Reactive oxygen species
Human dermal fibroblasts
Matrix metalloproteinases
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Summary:Highlights ▸ AAPE at 2 μg/ml specifically exhibits scavenging activity of hydrogen peroxide and reducing power. ▸ AAPE increases activities of MMP-1 and MMP-2 in human dermal fibroblasts. ▸ The level of MMP-1 expression is decreased in a dose dependent manner by AAPE. ▸ The expression level of p-ERK1 is reduced in the presence of AAPE compared with blank group. ▸ The expression level of c-Fos, a part of AP-1, is increased by AAPE.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2012.04.010