Overriding ortho selectivity by template assisted meta-C-H activation of benzophenones

An orthogonal selectivity for distalmeta-C-H activation of benzophenone is acheived by overriding the inherent proximalortho-selectivity through a template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C-C and C-Si bond formation.

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 56; no. 53; pp. 7281 - 7284
Main Authors Casali, Emanuele, Kalra, Prakriti, Brochetta, Massimo, Borsari, Tania, Gandini, Andrea, Patra, Tuhin, Zanoni, Giuseppe, Maiti, Debabrata
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.07.2020
Royal Society of Chemistry
Subjects
Activation
Chemistry
Chemistry, Multidisciplinary
Crystallography
Physical Sciences
Science & Technology
Selectivity
DIRECTING GROUP
FUNCTIONALIZATION
CROSS-COUPLING REACTIONS
HETEROARENES
OLEFINATION
HETEROCYCLES
ACYLATION
OXYGENATION
ARYLATION
BOND ACTIVATION
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Summary:An orthogonal selectivity for distalmeta-C-H activation of benzophenone is acheived by overriding the inherent proximalortho-selectivity through a template assisted metalation approach. This strategy has been successfully utilized in Pd-catalyzed regioselective C-C and C-Si bond formation.
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ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc03172k