Influence of labour on epidermal growth factor receptor distribution of the human chorion at term gestation

Chorion was obtained from 10 healthy pregnant women at term gestation who were delivered either vaginally (n = 5) or by elective repeat caesarean section before the onset of labour (n = 5). Epidermal growth factor (EGF) receptors in chorionic tissue were evaluated by means of freeze fracture techniq...

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Bibliographic Details
Published inGynecologic and obstetric investigation Vol. 35; no. 2; p. 99
Main Authors Pasetto, N, Petrozza, V, Ticconi, C, Zicari, A, Carpino, F, Piccione, E, Melis, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1993
Subjects
Binding Sites
Cesarean Section
Chorion - metabolism
Chorion - ultrastructure
Female
Freeze Fracturing
Humans
Labor, Obstetric - metabolism
Microscopy, Electron
Pregnancy
Receptor, Epidermal Growth Factor - analysis
Receptor, Epidermal Growth Factor - metabolism
Receptor, Epidermal Growth Factor - ultrastructure
Reoperation
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Summary:Chorion was obtained from 10 healthy pregnant women at term gestation who were delivered either vaginally (n = 5) or by elective repeat caesarean section before the onset of labour (n = 5). Epidermal growth factor (EGF) receptors in chorionic tissue were evaluated by means of freeze fracture technique (label fracture). They were found to be significantly less, but more frequently coupled, in specimens obtained after labour than before the onset of labour. These findings suggest that a functional activation of EGF receptors in human chorion might occur during labour.
ISSN:0378-7346
DOI:10.1159/000292674