Changes in tissue levels of glutathione, extent of lipid peroxidation, and activity of glutathione peroxidase in transplantable murine lymphoma

The reduced glutathione (GSH) levels in the hepatic tissues, extent of lipid peroxidation in the liver, kidney and brain, and alterations in the activity of glutathione peroxidase (GPX) in the hepatic tissues were monitored in mice bearing a transplantable ascitic lymphoma. These markers showed subs...

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Bibliographic Details
Published inOncology Vol. 51; no. 1; p. 25
Main Authors Rana, M P, Ghosh, R, Chatterjee, M
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1994
Subjects
Animals
Brain - enzymology
Brain - metabolism
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Kidney - enzymology
Kidney - metabolism
Lipid Peroxidation
Liver - enzymology
Liver - metabolism
Lymphoma - metabolism
Lymphoma - pathology
Male
Mice
Mice, Inbred Strains
Neoplasm Transplantation
Time Factors
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Summary:The reduced glutathione (GSH) levels in the hepatic tissues, extent of lipid peroxidation in the liver, kidney and brain, and alterations in the activity of glutathione peroxidase (GPX) in the hepatic tissues were monitored in mice bearing a transplantable ascitic lymphoma. These markers showed substantial alterations during the height of tumour progression when compared to controls. The GSH level, extent of lipid peroxidation, and GPX activity increased sharply after approximately 2 weeks following inoculation of ascitic cells. This was followed by a steady decline in all markers and death occurred around day 32 after inoculation.
ISSN:0030-2414
DOI:10.1159/000227305