Phytochemical screening and synergistic interactions between aminoglycosides, selected antibiotics and extracts from the bryophyte Octoblepharum albidum Hedw (Calymperaceae)

• Published in: Archives of biological sciences Vol. 64; no. 2; pp. 465 - 470
• Main Authors: Vidal, C.A.S., Regional University of Cariri, Crato, CE (Brazil). Laboratory of Natural Products Research, Sousa, E.O., Regional University of Cariri, Crato, CE (Brazil). Laboratory of Natural Products Research, Rodrigues, F.F.G., Regional University of Cariri, Crato, CE (Brazil). Laboratory of Natural Products Research, Campos, A.R., University of Fortaleza, Fortaleza-CE (Brazil). Vice-Rectory of Research and Post-Graduation, Lacerda, S.R., Regional University of Cariri, Crato, CE (Brazil). Laboratory of Natural Products Research, Costa, J.G.M., Regional University of Cariri, Crato, CE (Brazil). Laboratory of Natural Products Research
• Format: Journal Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2012
• Subjects: aminoglycosides; antibacterial activity; ANTIMICROBIAL PROPERTIES; BRYOPHYTA; EXTRACTOS VEGETALES; EXTRAIT D'ORIGINE VAGATALE; GLICOSIDOS; GLYCOSIDE; GLYCOSIDES; http://www.fao.org/aos/agrovoc#c_1129; http://www.fao.org/aos/agrovoc#c_26756; http://www.fao.org/aos/agrovoc#c_3309; http://www.fao.org/aos/agrovoc#c_8166; modification of resistance; Octoblepharum albidum Hedw; PLANT EXTRACTS; PROPIEDADES ANTIMICROBIANAS; PROPRIATA ANTIMICROBIENNE
• ISSN: 0354-4664; 1821-4339
• DOI: 10.2298/ABS1202465V

This work is the first to describe the modulation of antibiotic activity of the bryophyte Octoblepharum albidum Hedw extract. The antibacterial activity of ethanolic extract of O. albidum (EEOa), alone and in association with aminoglycosides, was determined against six bacterial strains by a microdilution test. The results showed a similar inhibitory activity of EEOa against Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 33018 (MICs 512 microg/mL). The synergistic effect of the extracts and aminoglycosides was also verified. The most pronounced effects were obtained with EEOa + gentamicin against E. coli and EEOa + kanamycin against K. pneumoniae with MICs reduction (128 to 32 microg/mL). The data from this study are indicative of the antibacterial activity of the bryophyte O. albidum extracts and its potential in modifying the resistance of aminoglycosides analyzed.