Immune response to hepatitis B vaccine in hemodialysis patients

The impaired immune reactivity of hemodialysis patients has been reported to interfere with adequate antibody responses to standard doses of hepatitis B vaccine. In 22 hemodialysis patients, however, a 92% conversion rate could be obtained by administering multiple doses of plasma-derived MSD-vaccin...

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Bibliographic Details
Published inNephron (2015) Vol. 45; no. 3; p. 216
Main Authors van Geelen, J A, Schalm, S W, de Visser, E M, Heijtink, R A
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Adolescent
Adult
Aged
Antibody Formation
Drug Administration Schedule
Female
Hepatitis B Vaccines
Humans
Male
Middle Aged
Renal Dialysis
Viral Hepatitis Vaccines - administration & dosage
Viral Hepatitis Vaccines - immunology
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Summary:The impaired immune reactivity of hemodialysis patients has been reported to interfere with adequate antibody responses to standard doses of hepatitis B vaccine. In 22 hemodialysis patients, however, a 92% conversion rate could be obtained by administering multiple doses of plasma-derived MSD-vaccine. As the cost of such an amplified vaccination schedule is still lower than the cost of one dialysis treatment, this active vaccination policy for highly susceptible patients appears financially justified.
ISSN:1660-8151
DOI:10.1159/000184120