Pyrone and pyridone compounds in the liquid culture of Physisporinus sanguinolentus

• Published in: Phytochemistry (Oxford) Vol. 56; no. 7; pp. 747 - 751
• Main Authors: Svensson, Marlene, Lundgren, Lennart N, Woods, Caroline, Fatehi, Jamshid, Stenlid, Jan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.04.2001; Elsevier
• Subjects: 4-Hydroxypyridine; 4-Pyridone; 4-Pyrone; Antifungal effect; Biological and medical sciences; Chemical control; Chromatography, High Pressure Liquid; Control; Culture Media; Dihydro-4-pyrone; Fundamental and applied biological sciences. Psychology; Fungal plant pathogens; Physisporinus sanguinolentus; Phytopathology. Animal pests. Plant and forest protection; Polyporaceae - physiology; Pyridones - analysis; Pyridones - chemistry; Pyrones - analysis; Pyrones - chemistry; Antifungal effect; 4-Pyrone; 4-Hydroxypyridine; 4-Pyridone; Dihydro-4-pyrone; Physisporinus sanguinolentus; Bioassay; Heterobasidion annosum; Molecular structure; Quinone; Pesticides; Basidiomycetes; Cladosporium cucumerinum; Pyranone derivatives; Biological activity; Fungicide; Spores; Fungi; Wood destroying fungi; Hypha; Microorganism culture; Development; Isolation; Fungi Imperfecti; Thallophyta
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)00414-3

Chromatographic separation of the liquid culture filtrate of the basidiomycete fungus Physisporinus sanguinolentus has yielded three new compounds viz., 2-methyl-4-pyrone, 2-methyl-5,6-dihydro-4-pyrone and the pyridone form of 4-hydroxy-2-methylpyridine, together with the known triacetic acid lactone, the sesquiterpene dialdehyde merulidial and a derivative of merulidial. Their structures were elucidated by spectroscopic analysis and by comparison to literature data and a synthetic sample. One of the compounds, merulidial, was shown to inhibit the germination of spores and the hyphal growth of the wood-rotting basidiomycete Heterobasidion annosum and the saprophytic mould Cladosporium cucumerinum.