Therapeutic combination of sildenafil and iloprost in a preterm neonate with pulmonary hypertension

• Published in: Pediatric pulmonology Vol. 46; no. 6; pp. 617 - 620
• Main Authors: Gürakan, Berkan, Kayıran, Petek, Öztürk, Nilüfer, Kayıran, Sinan Mahir, Dindar, Aygün
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2011; Wiley-Liss
• Subjects: Administration, Inhalation; Administration, Oral; Biological and medical sciences; bronchopulmonary dysplasia; Bronchopulmonary Dysplasia - complications; Diseases of mother, fetus and pregnancy; Drug Therapy, Combination; General aspects; Gynecology. Andrology. Obstetrics; Human viral diseases; Humans; Hypertension, Pulmonary - drug therapy; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - physiopathology; Hypoxia - complications; Iloprost - administration & dosage; Iloprost - therapeutic use; Infant; Infant, Newborn; Infant, Premature; Infectious diseases; Male; Medical sciences; Piperazines - administration & dosage; Piperazines - therapeutic use; Pneumology; Pregnancy. Fetus. Placenta; pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Purines - administration & dosage; Purines - therapeutic use; respiratory syncytial virus; Respiratory Syncytial Virus Infections - complications; Sildenafil Citrate; Sulfones - administration & dosage; Sulfones - therapeutic use; Treatment Outcome; Vasodilator Agents - administration & dosage; Vasodilator Agents - therapeutic use; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Human; Premature; Human respiratory syncytial virus; Lung disease; Pediatrics; Iloprost; Pneumovirinae; Respiratory disease; Cardiovascular disease; Pulmonary hypertension; Paramyxoviridae; Virus; Mononegavirales; Newborn diseases; Newborn; Treatment; Prematurity; Bronchus disease; Bronchopulmonary dysplasia; Sildenafil; Pneumovirus; respiratory syncytial virus; Pneumology
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.21415

While new pharmacological approaches have been demonstrated to effectively manage PH in adults, few reports have addressed PH treatment in neonates and infants. This case report describes the successful management of severe PH secondary to bronchopulmonary dysplasia, respiratory syncytial virus infection, and hypoxia in a preterm 4‐month‐old with the long‐term use of orally administered sildenafil and inhaled iloprost. Pediatr. Pulmonol. 2011; 46:617–620. © 2011 Wiley‐Liss, Inc.