Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes

The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. 42 compounds inhibited the TAK-induced activation of PMN....

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Published inPlanta medica Vol. 58; no. 2; p. 137
Main Authors Kinoshita, K, Morikawa, K, Fujita, M, Natori, S
Format Journal Article
LanguageEnglish
Published Germany 01.04.1992
Subjects
Animals
chemical composition
cinchona
composicion quimica
composition chimique
Cytotoxicity, Immunologic - drug effects
drug plants
fitotoxicidad
Free Radical Scavengers
hydrangea
inhibicion
inhibition
magnolia
Male
metabolite
metabolites
metabolitos
Mice
Mice, Inbred C3H
neoplasmas
neoplasme
neoplasms
Neutrophils - drug effects
Neutrophils - immunology
phytotoxicite
phytotoxicity
Plant Extracts - chemistry
Plant Extracts - pharmacology
plantas medicinales
plante medicinale
Plants, Medicinal
rauvolfia
solanaceae
Tumor Cells, Cultured
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Abstract The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. 42 compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.
AbstractList The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. Forty-two compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.
The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. 42 compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.
Author Morikawa K
Kinoshita K
Fujita M
Natori S
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crossref_primary_10_1016_S0040_4020_99_00917_5
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crossref_primary_10_1007_BF02873592
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StartPage 137
SubjectTerms Animals
chemical composition
cinchona
composicion quimica
composition chimique
Cytotoxicity, Immunologic - drug effects
drug plants
fitotoxicidad
Free Radical Scavengers
hydrangea
inhibicion
inhibition
magnolia
Male
metabolite
metabolites
metabolitos
Mice
Mice, Inbred C3H
neoplasmas
neoplasme
neoplasms
Neutrophils - drug effects
Neutrophils - immunology
phytotoxicite
phytotoxicity
Plant Extracts - chemistry
Plant Extracts - pharmacology
plantas medicinales
plante medicinale
Plants, Medicinal
rauvolfia
solanaceae
Tumor Cells, Cultured
Title Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes
URI https://www.ncbi.nlm.nih.gov/pubmed/1529025
Volume 58
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