Inhibitory effects of plant secondary metabolites on cytotoxic activity of polymorphonuclear leucocytes

• Published in: Planta medica Vol. 58; no. 2; p. 137
• Main Authors: Kinoshita, K, Morikawa, K, Fujita, M, Natori, S
• Format: Journal Article
• Language: English
• Published: Germany 01.04.1992
• Subjects: Animals; chemical composition; cinchona; composicion quimica; composition chimique; Cytotoxicity, Immunologic - drug effects; drug plants; fitotoxicidad; Free Radical Scavengers; hydrangea; inhibicion; inhibition; magnolia; Male; metabolite; metabolites; metabolitos; Mice; Mice, Inbred C3H; neoplasmas; neoplasme; neoplasms; Neutrophils - drug effects; Neutrophils - immunology; phytotoxicite; phytotoxicity; Plant Extracts - chemistry; Plant Extracts - pharmacology; plantas medicinales; plante medicinale; Plants, Medicinal; rauvolfia; solanaceae; Tumor Cells, Cultured
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-2006-961415

The inhibitory effects of 151 natural products, representing most of the frequently occurring types, on the cytotoxicity to MM2 tumor cells of polymorphonuclear leucocytes (PMN) induced by TAK, a polysaccharide immunomodulator, were examined. 42 compounds inhibited the TAK-induced activation of PMN. Among them, some naturally occurring quinones and various alkaloids (nicotine, Cinchona alkaloids, isoquinoline alkaloids such as cepharanthine, and indole alkaloids such as ajmaline) exhibited potent inhibitory effects. Using the inhibition assay for monitoring, the extracts of Hydrangea Dulcis folium, Scopoliae rhizoma, Cinchona cortex, Magnoliae cortex, Stephania tuber, and Rauwolfia radix were analysed to characterize the active constituents.