Synthesis and In-Vitro Activity of New 1β-Methylcarbapenem Derivatives as Antibacterial Agents

The synthesis of a new series of 1β‐methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particul...

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Published inArchiv der Pharmazie (Weinheim) Vol. 341; no. 12; pp. 780 - 786
Main Authors Jung, Myung-Ho, Hong, Joon Hee, Cho, Jung-Hyuck, Oh, Chang-Hyun
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2008
WILEY‐VCH Verlag
Wiley
Subjects
1β-Methylcarbapenems
Antibacterial activity
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical Sciences
Science & Technology
Substituent effects
Substituent effects
Antibacterial activity
CARBAPENEM ANTIBIOTICS
1 beta-Methylcarbapenems
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Summary:The synthesis of a new series of 1β‐methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound III b having an oxime‐pyrrolidine moiety showed the most potent antibacterial activity.
Bibliography:istex:3EA09663B22CB85A893667438DC0D0E9DB3D2447
Hawon Pharmaceutical Co.
ark:/67375/WNG-BVP4VCVG-C
ArticleID:ARDP200800014
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200800014