Lectin-like receptor for α1-acid glycoprotein in the epithelium of the rat prostate gland and seminal vesicles
BACKGROUND A receptor for α1‐acid glycoprotein glycoforms AGP‐B and AGP‐C in the epithelium of the rat prostate gland and seminal vesicles is described. METHODS The interaction between AGP‐glycoforms and their receptor is a lectin‐like interaction confirmed by inhibition of the binding by mannose an...
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Published in | The Prostate Vol. 29; no. 6; pp. 356 - 361 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
01.12.1996
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | BACKGROUND
A receptor for α1‐acid glycoprotein glycoforms AGP‐B and AGP‐C in the epithelium of the rat prostate gland and seminal vesicles is described.
METHODS
The interaction between AGP‐glycoforms and their receptor is a lectin‐like interaction confirmed by inhibition of the binding by mannose and N‐Acetyl‐D‐glucosamine.
RESULTS
In vitro the receptor was also inhibited by the steroid hormones cortisone, aldosterone, progesterone, and estradiol, but not by testosterone. A significant regional variation in the expression of AGP‐lectin receptor and in the localization of AGP was seen in rat prostate and seminal vesicles. The localization of the AGP lectin receptor is compared to the localization of glycoprotein AGP, and small differences are found.
CONCLUSIONS
It is proposed the AGP receptors in the prostate and seminal vesicles belong to a group of lectins in the control of differentiation and organ formation. © 1996 Wiley‐Liss, Inc. |
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Bibliography: | ArticleID:PROS3 ark:/67375/WNG-8VDLG8G7-Q istex:21CC0AC104EE413BE92FD28B37D06ED6DF8ED37C Direktor Jacob Madsens and Hustru Olga Madsens Fond |
ISSN: | 0270-4137 1097-0045 |
DOI: | 10.1002/(SICI)1097-0045(199612)29:6<356::AID-PROS3>3.0.CO;2-6 |