Effects of Finasteride (1 mg) on Hair Transplant

• Published in: Dermatologic surgery Vol. 31; no. 10; pp. 1268 - 1276
• Main Authors: Leavitt, Matt, David, Perez-Meza, Rao, Naveen A, Barusco, Marco, Kaufman, Keith D, Ziering, Craig
• Format: Journal Article
• Language: English
• Published: United States by the American Society for Dermatologic Surgery, Inc 01.10.2005
• Subjects: Adult; Alopecia - drug therapy; Alopecia - surgery; Double-Blind Method; Drug Administration Schedule; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - therapeutic use; Finasteride - administration & dosage; Finasteride - therapeutic use; Hair - drug effects; Hair - transplantation; Humans; Male; Middle Aged; Treatment Outcome
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1097/00042728-200510000-00002

BACKGROUNDThe improved scalp coverage achieved by hair transplant for men with androgenetic alopecia can be diminished by continued miniaturization and loss of preexisting, nontransplanted hairs. OBJECTIVESTo evaluate whether finasteride 1 mg, administered daily from 4 weeks before until 48 weeks after hair transplant, improves scalp hair and growth of nontransplanted hair in areas surrounding the transplant and to evaluate the safety and tolerability of finasteride for men undergoing hair transplant. METHODSIn this randomized, double-blind, placebo-controlled study, 79 men with androgenetic alopecia (20–45 years of age) were assigned to treatment with finasteride 1 mg (n = 40) or placebo (n = 39) once daily from 4 weeks before until 48 weeks after hair transplant. Efficacy was evaluated by review of global photographs by an expert dermatologist and by macrophotography for scalp hair counts. RESULTSTreatment with finasteride resulted in significant improvements from baseline, compared with placebo, in scalp hair based on global photographic assessment (p < .01) and hair counts (p < .01) at week 48. Visible increases in superior/frontal scalp hair post-transplant were recorded for 94% and 67% of patients in the finasteride and placebo groups, respectively. Finasteride treatment was generally well tolerated. CONCLUSIONFor men with androgenetic alopecia, therapy with finasteride 1 mg daily from 4 weeks before until 48 weeks after hair transplant improves scalp hair surrounding the hair transplant and increases hair density.