Cancer-preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray

• Published in: Phytotherapy research Vol. 24; no. 11; pp. 1730 - 1732
• Main Authors: Mechikova, G. Ya, Kuzmich, A. S., Ponomarenko, L. P., Kalinovsky, A. I., Stepanova, T. A., Fedorov, S. N., Stonik, V. A.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2010
• Subjects: Animals; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacokinetics; caffeic acid; Caffeic Acids - isolation & purification; Caffeic Acids - pharmacology; cancer-preventive effect; Cell Line, Tumor; chlorogenic acid; Chlorogenic Acid - isolation & purification; Chlorogenic Acid - pharmacology; flavonoids; Flavonoids - isolation & purification; Flavonoids - pharmacology; HeLa Cells; Humans; Mice; Molecular Structure; Plant Extracts - pharmacology; Plant Leaves - chemistry; Vaccinium myrtillus - chemistry; Vaccinium smallii
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.3282

Ten secondary metabolites including flavonoids (1–8), caffeic (9) and chlorogenic (10) acids were structurally identified from the extract of Sakhalin bilberry Vaccinium smallii leaves and studied in vitro as potential cancer‐preventive agents. The results showed that compounds 1–10 inhibited EGF‐induced neoplastic transformation of mouse JB6 Cl 41 P+ cells in soft agar with an inhibition concentration (INCC50) of 20–80 µm. Moreover, all these natural products were non‐toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm. Copyright © 2010 John Wiley & Sons, Ltd.