Frequency doubling technology perimetry with the Humphrey Matrix 30-2 test

• Published in: Journal of glaucoma Vol. 15; no. 2; p. 77
• Main Authors: Brusini, Paolo, Salvetat, Maria Letizia, Zeppieri, Marco, Parisi, Lucia
• Format: Journal Article
• Language: English
• Published: United States 01.04.2006
• Subjects: Adult; Aged; Aged, 80 and over; Area Under Curve; Cross-Sectional Studies; Female; Glaucoma, Open-Angle - diagnosis; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension - diagnosis; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Vision Disorders - diagnosis; Visual Field Tests - methods; Visual Fields
• ISSN: 1057-0829
• DOI: 10.1097/00061198-200604000-00001

To assess the Humphrey Matrix 30-2 test in detecting functional glaucomatous damage. One eye in each of 60 healthy individuals, 108 patients with ocular hypertension (OHT), and 150 patients with preperimetric (48) or perimetric (102) high-tension primary open-angle glaucoma (POAG) were considered. Visual fields were assessed by the standard automated perimetry (SAP) Humphrey Field Analyzer 30-2, frequency doubling technology (FDT) N-30, and Humphrey Matrix 30-2 tests. Significantly abnormal points in the pattern deviation probability plot, testing time, sensitivity, specificity, and area under the receiver operating characteristic curve of the FDT tests were evaluated. FDT revealed a significantly greater percentage of depressed points than did SAP in OHT and preperimetric POAG eyes. The FDT-N-30 test showed a significantly greater percentage of areas with P < 5% in the OHT, preperimetric POAG, and early POAG groups. The Matrix-30-2 test provided an area under the receiver operating characteristic curve slightly lower than the FDT-N-30 test in the preperimetric POAG group, and significantly greater in the perimetric POAG group. FDT perimetry appeared more sensitive than SAP in detecting early glaucomatous VF loss. The FDT-N-30 test showed a slightly higher ability to detect early glaucomatous damage in patients at risk for the development of glaucoma, whereas the Matrix-30-2 test provided a more detailed characterization of the glaucomatous VF loss pattern, although it required 30% more time.