Near-ultraviolet sensitivity of skin fibroblasts of patients with bloom's syndrome

Near-ultraviolet survival of colony forming ability was compared between fibroblast strains from normal individuals and seven strains from Bloom's Syndrome patients using monochromatic light at 313 nm. Six BS strains possessed abnormal survival properties. Two strains lacked the low dose should...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 98; no. 3; pp. 579 - 587
Main Authors Zbinden, Irène, Cerutti, Peter
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.02.1981
Subjects
Cell Survival - radiation effects
Cells, Cultured
Fibroblasts - radiation effects
Humans
Photosensitivity Disorders - pathology
Skin - radiation effects
Syndrome
Ultraviolet Rays - adverse effects
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Summary:Near-ultraviolet survival of colony forming ability was compared between fibroblast strains from normal individuals and seven strains from Bloom's Syndrome patients using monochromatic light at 313 nm. Six BS strains possessed abnormal survival properties. Two strains lacked the low dose shoulder, which is characteristic for normal fibroblasts, but their overall sensitivity was in the normal range. Four BS strains were hypersensitive and possessed biphasic survival curves with a sharp initial drop. They mimick in culture the characteristic solar sensitivity of BS patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(81)91154-2