The influence of testosterone on purine nucleotide metabolism in rat liver

Purine nucleotide metabolism was studied in rat liver by following the incorporation of 14C-formate into soluble nucleotides, uric acid and RNA ribonucleotides. After castration, GMP formation was less than that of AMP, and purine nucleotide catabolism and RNA synthesis decreased. Testosterone admin...

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Bibliographic Details
Published inLife sciences (1973) Vol. 57; no. 23; pp. 2127 - 2135
Main Authors Pizzichini, M., Leoncini, R., Vannoni, D., Marinello, E., Pagani, R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 1995
Subjects
Animals
Formates - metabolism
liver
Liver - metabolism
Male
Orchiectomy
purine nucleotide
Purine Nucleotides - metabolism
Rats
Rats, Wistar
testosterone
Testosterone - pharmacology
testosterone
purine nucleotide
liver
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Summary:Purine nucleotide metabolism was studied in rat liver by following the incorporation of 14C-formate into soluble nucleotides, uric acid and RNA ribonucleotides. After castration, GMP formation was less than that of AMP, and purine nucleotide catabolism and RNA synthesis decreased. Testosterone administration did not modify GMP or AMP synthesis, but restored purine nucleotide catabolism and RNA production to normal values. These results demonstrate the influence of testosterone on purine nucleotide metabolism in a non-reproductive organ.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(95)02205-W