Micronuclei, kinetochores and hypoploidy: tests with some agents

Micronuclei were induced by treating mouse L-cells with diethylstilboestrol, colchicine and benomyl. These micronuclei were analysed for the presence of kinetochores by using antikinetochore antibody. The three chemicals induced micronuclei which differed with regards to their (i) relative distribut...

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Bibliographic Details
Published inMutagenesis Vol. 4; no. 6; p. 425
Main Authors Sternes, K L, Vig, B K
Format Journal Article
LanguageEnglish
Published England 01.11.1989
Subjects
Alkylating Agents - pharmacology
Aneuploidy
Animals
Benomyl - pharmacology
Chromosomes - drug effects
Colchicine - pharmacology
Diethylstilbestrol - pharmacology
Humans
Mice
Micronucleus Tests
Mutagens - pharmacology
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Summary:Micronuclei were induced by treating mouse L-cells with diethylstilboestrol, colchicine and benomyl. These micronuclei were analysed for the presence of kinetochores by using antikinetochore antibody. The three chemicals induced micronuclei which differed with regards to their (i) relative distribution per cell, (ii) relative frequency for being kinetochore positive or being kinetochore negative and (iii) overall relationship between their induction and hypoploidy which in part may originate from laggards expressing as micronuclei. The data indicate that a study of micronuclei may help determine the differences between the actions of different chemicals on the genetic apparatus.
ISSN:0267-8357
DOI:10.1093/mutage/4.6.425