Plasma apolipoprotein profiles of male and female rats

To determine if sex differences exist in the apolipoprotein profile of the rat, the concentrations of the major apolipoproteins and lipids of 12-week-old male and female rats were measured in the plasma as well as in the individual lipoprotein fractions. Plasma apo B, triglyceride, and cholesterol c...

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Bibliographic Details
Published inAtherosclerosis Vol. 37; no. 4; pp. 569 - 577
Main Authors Van Lenten, Brian J., Jenkins, Christine H., Roheim, Paul S.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.12.1980
Subjects
Animals
Apolipoproteins
Apolipoproteins - blood
Body Weight
Cholesterol
Cholesterol - blood
Female
Lipoproteins - blood
Male
Rats
Sex differences
Sex Factors
Triglycerides
Triglycerides - blood
Sex differences
Triglycerides
Apolipoproteins
Cholesterol
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Summary:To determine if sex differences exist in the apolipoprotein profile of the rat, the concentrations of the major apolipoproteins and lipids of 12-week-old male and female rats were measured in the plasma as well as in the individual lipoprotein fractions. Plasma apo B, triglyceride, and cholesterol concentrations were significantly higher in male rats than in female rats. Plasma concentrations of apo A-I, apo E, apo A-IV, and apo CIII did not differ between the sexes. Male rats had higher concentrations of apo B in the very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and the low density lipoproteins (LDL). These results further support the evidence that sex hormones influence lipoprotein metabolism in the rat.
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SourceType-Scholarly Journals-1
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ISSN:0021-9150
1879-1484
DOI:10.1016/0021-9150(80)90064-7