The activity of 2-(2′,4′-diaminophenoxy)ethanol in 3 genetic toxicity bioassays
2-(2′,4′-Diaminophenoxy)-ethanol, a hair-dye ingredient was evaluated for genetic activity in vitro using urine collected from mice in an Ames test and in vivo using the mouse dominant-lethal assay and the mouse spot test for somatic mutation detection. All 3 studies were conducted using dermal appl...
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Published in | Mutation Research/Genetic Toxicology Vol. 102; no. 4; pp. 361 - 372 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.12.1982
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Subjects | |
Online Access | Get full text |
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Summary: | 2-(2′,4′-Diaminophenoxy)-ethanol, a hair-dye ingredient was evaluated for genetic activity in vitro using urine collected from mice in an Ames test and in vivo using the mouse dominant-lethal assay and the mouse spot test for somatic mutation detection. All 3 studies were conducted using dermal application of the dye material to shaved skin. The applied dose levels ranged from 15 to 1500 mg/kg body weight.
The results of these 3 studies were considered to be negative although urine analysis and spot-test data showed non-significant dose-related increases. |
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ISSN: | 0165-1218 0027-5107 |
DOI: | 10.1016/0165-1218(82)90099-4 |