The activity of 2-(2′,4′-diaminophenoxy)ethanol in 3 genetic toxicity bioassays

2-(2′,4′-Diaminophenoxy)-ethanol, a hair-dye ingredient was evaluated for genetic activity in vitro using urine collected from mice in an Ames test and in vivo using the mouse dominant-lethal assay and the mouse spot test for somatic mutation detection. All 3 studies were conducted using dermal appl...

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Bibliographic Details
Published inMutation Research/Genetic Toxicology Vol. 102; no. 4; pp. 361 - 372
Main Authors Brusick, D.J., Jagannath, D.R., Matheson, D.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.1982
Subjects
Alleles
Animals
Crosses, Genetic
Embryo Implantation - drug effects
Female
Fertility - drug effects
Hair Dyes - pharmacology
Hair Preparations - pharmacology
Heterozygote
Male
Mice
Mice, Inbred C57BL
Mutagenicity Tests
Mutagens
Mutation
Phenylenediamines - pharmacology
Pregnancy
Salmonella typhimurium - drug effects
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Summary:2-(2′,4′-Diaminophenoxy)-ethanol, a hair-dye ingredient was evaluated for genetic activity in vitro using urine collected from mice in an Ames test and in vivo using the mouse dominant-lethal assay and the mouse spot test for somatic mutation detection. All 3 studies were conducted using dermal application of the dye material to shaved skin. The applied dose levels ranged from 15 to 1500 mg/kg body weight. The results of these 3 studies were considered to be negative although urine analysis and spot-test data showed non-significant dose-related increases.
ISSN:0165-1218
0027-5107
DOI:10.1016/0165-1218(82)90099-4