Increase in insulin secretion induced by plasma from mice injected with allogeneic lymphocytes

Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a...

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Bibliographic Details
Published inHormone and metabolic research Vol. 19; no. 7; p. 290
Main Authors García, J B, Venturino, M C, Cresto, J C, Pivetta, O H, Basabe, J C
Format Journal Article
LanguageEnglish
Published Germany 01.07.1987
Subjects
Animals
Diabetes Mellitus, Experimental - immunology
Diabetes Mellitus, Experimental - physiopathology
Female
Glucose - pharmacology
In Vitro Techniques
Insulin - metabolism
Insulin Secretion
Isoantigens - administration & dosage
Lymphocytes - immunology
Male
Mice
Mice, Inbred Strains
Pancreas - metabolism
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Summary:Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a significant increase on insulin secretion. This effect is seen when mice are bled between 60 and 180 minutes after injection with a maximum effect at 90-120 minutes. Plasma from BALB/c mice injected with C57BL/6 J lymphocytes rises insulin secretion from BALB/c, C57BL/6 J, C3h and C57BL/KsJ mice pancreas. Plasma from streptozotocin diabetic BALB/c mice and from genetically diabetic C57BL/KsJ mdb-mdb mice injected with allogeneic lymphocytes stimulates glucose induced insulin secretion but to a lesser extent than plasma from normal non-diabetic mice does.
ISSN:0018-5043
DOI:10.1055/s-2007-1011803