The ganglion-blocked, angiotensin II-supported rat: a model for demonstrating antihypertensive vasodilator activity

This report describes the implementation of an in vivo method for demonstrating direct vasodilator activity of potential antihypertensive agents. The experimental model is an anesthetized, ganglion-blocked rat whose blood pressure is maintained by an intravenous infusion of angiotensin II. A hypoten...

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Bibliographic Details
Published inJournal of pharmacological methods Vol. 3; no. 4; p. 311
Main Authors Deitchman, D, Braselton, J P, Hayes, D C, Stratman, R L
Format Journal Article
LanguageEnglish
Published United States 01.06.1980
Subjects
Angiotensin II - pharmacology
Animals
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Ganglionic Blockers - pharmacology
Hindlimb - blood supply
Hypertension - chemically induced
Male
Models, Biological
Rats
Regional Blood Flow - drug effects
Time Factors
Vasodilation - drug effects
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Summary:This report describes the implementation of an in vivo method for demonstrating direct vasodilator activity of potential antihypertensive agents. The experimental model is an anesthetized, ganglion-blocked rat whose blood pressure is maintained by an intravenous infusion of angiotensin II. A hypotensive response in this model appears to correlate more closely with antihypertensive activity in desoxycorticosterone acetate (DOCA)-salt hypertensive rats than does a vasodilator response in the pump-perfused hind limb of anesthetized dogs. Furthermore, it distinguishes between vasodilators that are effective in hypertension, eg hydralazine and diazoxide, and vasodilators that are used to treat peripheral vascular disease, eg cinnarizine and papaverine.
ISSN:0160-5402
DOI:10.1016/0160-5402(80)90073-X