Uterine choriocarcinoma with negative specific serum radioimmunoassay for human chorionic gonadotropins

A case of uterine choriocarcinoma complicating gestational trophoblastic disease is presented. Following chemotherapy, there seemed to be an apparent cure as indicated by follow-up monitoring of the beta subunit of human chorionic gonadotropin (B-HCG assay) when the assay demonstrated three consecut...

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Bibliographic Details
Published inGynecologic oncology Vol. 14; no. 1; pp. 112 - 118
Main Authors Bakri, Younes, Lee, James H., Jahshan, Antoine E., Lewis, George C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1982
Subjects
Adult
Choriocarcinoma - blood
Choriocarcinoma - pathology
Chorionic Gonadotropin - blood
False Negative Reactions
Female
Humans
Pregnancy
Radioimmunoassay
Uterine Neoplasms - blood
Uterine Neoplasms - pathology
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Summary:A case of uterine choriocarcinoma complicating gestational trophoblastic disease is presented. Following chemotherapy, there seemed to be an apparent cure as indicated by follow-up monitoring of the beta subunit of human chorionic gonadotropin (B-HCG assay) when the assay demonstrated three consecutive weekly negative results. At the same period when the assays were negative, the patient was manifesting irregular vaginal bleeding for which diagnostic D&C was done revealing persistant disease which was not detected by measurement with the sensitive quantitiative B-HCG assay. The case is discussed to confirm the fact that clinical assessment is necessary for the follow-up of trophoblastic disease in addition to quantitative B-HCG.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0090-8258
1095-6859
DOI:10.1016/0090-8258(82)90057-9