Dietary quinine has a nongustatory effect on food intake in rats

• Published in: Pharmacology, biochemistry and behavior Vol. 18; no. 4; pp. 593 - 599
• Main Authors: Gunion, Mark W., Peters, Ronald H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.1983
• Subjects: Animals; Body weight; Body Weight - drug effects; Diet; Dietary quinine; Drug metabolism; Environment; Enzyme induction; Feeding Behavior - drug effects; Female; Food intake; Hepatic mixed-function microsomal oxidation system; Phenobarbital; Phenobarbital - pharmacology; Quinine - pharmacology; Rats; Taste - drug effects; Phenobarbital; Food intake; Enzyme induction; Body weight; Dietary quinine; Drug metabolism; Hepatic mixed-function microsomal oxidation system
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/0091-3057(83)90286-1

Recent data suggests that quinine adulteration of rats' maintenance diets may suppress food intake by postingestional (i.e., pharmacological or toxicological) mechanisms. This possibility was tested by increasing rats' rates of drug excretion prior to presentation of quinine maintenance diets. This treatment increased consumption of 3 concentrations (0.1, 0.2, 0.4%) of quinine diet in 2 separate experiments. In a third experiment, the same treatment did not alter consumption of quinine water in a 2 bottle test, suggesting that the increased consumption of quinine adulterated food was not due to a generalized decrease in the gustatory aversiveness of quinine. The data directly support the idea that quinine has postingestional effects which account for at least part of the suppression of food intake seen with quinine adulterated diets. The data further suggest that at least some of these effects occur postabsorptively.