Older and wiser: The benefits to neonates of aged neutrophils

Neonates are relatively protected from non-neonatal pathogens by unclear mechanisms. In this issue of Immunity, Bee et al.1 show that resistance to Streptococcus pneumoniae in neonatal mice is mediated by dampened neutrophil efferocytosis, accumulation of aged neutrophils, and enhanced CD11b-depende...

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Published inImmunity (Cambridge, Mass.) Vol. 56; no. 6; pp. 1157 - 1159
Main Authors B. Collins, George, Gilroy, Derek
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.06.2023
Subjects
Animals
Bees
Mice
Neutrophils
Phagocytosis
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Summary:Neonates are relatively protected from non-neonatal pathogens by unclear mechanisms. In this issue of Immunity, Bee et al.1 show that resistance to Streptococcus pneumoniae in neonatal mice is mediated by dampened neutrophil efferocytosis, accumulation of aged neutrophils, and enhanced CD11b-dependent bacterial opsonophagocytosis. Neonates are relatively protected from non-neonatal pathogens by unclear mechanisms. In this issue of Immunity, Bee et al. show that resistance to Streptococcus pneumoniae in neonatal mice is mediated by dampened neutrophil efferocytosis, accumulation of aged neutrophils, and enhanced CD11b-dependent bacterial opsonophagocytosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2023.05.012