Stereospecific distribution of fatty acids in human plasma triglycerides

Because of a biological difference between both primary hydroxylgroups of glycerol there are three distinct hydroxylgroups esterified with fatty acids in triglycerides. The distribution of fatty acids in the three distinct positions of triglycerides can be investigated by a combination of partial hy...

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Bibliographic Details
Published inClinica chimica acta Vol. 66; no. 1; pp. 43 - 52
Main Authors Parijs, J., De Weerdt, G.A., Beke, R., Barbier, F.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 02.01.1976
Subjects
Chromatography, Gas - methods
Fatty Acids - blood
Humans
Hyperlipidemias - blood
Lipase
Oleic Acids - blood
Palmitic Acids - blood
Pancreas - enzymology
Phospholipases
Stereoisomerism
Triglycerides - blood
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Summary:Because of a biological difference between both primary hydroxylgroups of glycerol there are three distinct hydroxylgroups esterified with fatty acids in triglycerides. The distribution of fatty acids in the three distinct positions of triglycerides can be investigated by a combination of partial hydrolysis of triglycerides by pancreatic lipase, phosphorylation of the diglycerides formed and the stereospecific action of phospholipase A on phosphatides. Plasma triglycerides from normal and hyperlipemic humans are analysed. Human plasma triglycerides are highly asymmetric. The 1-position contains more than twice as much palmitic acid as the 3-position. Statistically significant differences are found between normal and hyperlipemic humans for palmitic and linoleic acid at the 2-position, and for oleic and linoleic acid at the 3-position.
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SourceType-Scholarly Journals-1
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ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(76)90369-7