Lectin binding to mouse blood lymphocytes during tumor growth

Binding of FITC-labeled lectins to lymphocytes from intact mice and mice with transplanted Ehrlich carcinoma and CaO-1 ovarian carcinoma was studied by flow cytofluorometry. Specific binding of lectins by mannose and N-acetylgalactosamine was demonstrated. Lectin binding to lymphocytes from animals...

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Published inBulletin of experimental biology and medicine Vol. 140; no. 4; pp. 445 - 448
Main Authors Sitdikova, S M, Amandzholov, B S, Kiselevskii, M V, Donenko, F V
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.10.2005
Subjects
Acetylgalactosamine - chemistry
Animals
Carcinoma - immunology
Carcinoma - pathology
Carcinoma, Ehrlich Tumor - immunology
Carcinoma, Ehrlich Tumor - pathology
Female
Flow Cytometry
Fluorescein-5-isothiocyanate - chemistry
Lectins - chemistry
Lectins - immunology
Lymphocytes - immunology
Male
Mannose - chemistry
Mice
Mice, Inbred C57BL
Ovarian Neoplasms - immunology
Ovarian Neoplasms - pathology
Plant Lectins - chemistry
Plant Lectins - immunology
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Summary:Binding of FITC-labeled lectins to lymphocytes from intact mice and mice with transplanted Ehrlich carcinoma and CaO-1 ovarian carcinoma was studied by flow cytofluorometry. Specific binding of lectins by mannose and N-acetylgalactosamine was demonstrated. Lectin binding to lymphocytes from animals with tumors decreased by more than 50% in comparison with intact animals. Changed protein glycosylation during tumor growth is specific and differs for tumors of different origin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0515-8